| Autor: |
I, Bursuker, K M, Neddermann, B A, Petty, B, Schacter, G L, Spitalny, M A, Tepper, R D, Pasternak |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Experimental hematology. 20(4) |
| ISSN: |
0301-472X |
| Popis: |
Injection of mice with either natural bovine bone-derived or human recombinant transforming growth factor beta 1 (TGF-beta 1) resulted in a significant increase of the macrophage and macrophage-granulocyte-forming capacity of their macrophage colony-stimulating factor (M-CSF)- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent bone marrow precursor cells. The increased potential for generating granulocytes and/or macrophages from bone marrow cells of mice injected with TGF-beta 1 was associated with an increase of the number of M-CSF- and GM-CSF-dependent bone marrow colony-forming units (CFU). The effect was selective, in that in vivo applied TGF-beta 1 did not affect interleukin 3 (IL-3)-dependent CFU. The data suggest that TGF-beta may be useful in recovery of bone marrow granulocyte- and macrophage-forming potentials following depletion caused by chemo- or radiotherapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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