Autor: |
Olivier T, Giger, Rogier, Ten Hoopen, David, Shorthouse, Shukri, Abdullahi, Venkata Ramesh, Bulusu, Saili, Jadhav, Eamonn R, Maher, Ruth T, Casey |
Rok vydání: |
2022 |
Zdroj: |
Journal of clinical pathology. |
ISSN: |
1472-4146 |
Popis: |
Wild-type gastrointestinal stromal tumours (wtGIST) are frequently caused by inherited pathogenic variants, or somatic alterations in the succinate dehydrogenase subunit genes (MGMT methylation analysis was performed on 65 tumour samples including 47 wtGIST (33 SDH-deficient wtGIST and 11 SDH preserved wtGIST) and 21 tyrosine kinase (TK) mutant GIST.MGMT promoter hypermethylation occurs exclusively in a subset of dSDH wtGIST. Data from this study support testing of tumour MGMT promoter methylation in patients with dSDH wtGIST to identify those patients who may benefit from most from TMZ therapy. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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