[Efficacy of intraoperative hypotonic peritoneal chemo-hyperthermia combined with early postoperative intraperitoneal chemotherapy on gastric cancer]
| Autor: | Guo, Wei, Guo-En, Fang, Jian-Wei, Bi, Xiao-Jun, Shen, Ming-Ming, Nie, Xu-Chao, Xue, Ji-De, Hua |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Intraoperative Care Liver Neoplasms Hyperthermia Induced Middle Aged Combined Modality Therapy Survival Rate Hypotonic Solutions Gastrectomy Stomach Neoplasms Antineoplastic Combined Chemotherapy Protocols Humans Female Infusions Parenteral Peritoneal Lavage Fluorouracil Cisplatin Aged Follow-Up Studies Neoplasm Staging |
| Zdroj: | Ai zheng = Aizheng = Chinese journal of cancer. 24(4) |
| Popis: | Abdominal recurrence from exfoliated cancer cells contributes a lot to treatment failure of advanced gastric cancer. Intraperitoneal chemotherapy, which has been proved effective in eliminating exfoliated cancer cells in abdominal cavity, is a hot topic on treatment of gastric cancer. This study was to explore application of combined therapy of intraoperative hypotonic peritoneal chemo-hyperthermia and early postoperative intraperitoneal chemotherapy to gastric cancer.A total of 156 gastric cancer patients were randomized into 3 groups, and underwent the combined therapy (treatment group 1), intraoperative chemotherapy (treatment group 2), and peritoneal lavage with distilled water (control group), respectively.The 2-year survival rate of treatment group 1 was significantly higher than that of control group (88.4% vs. 65.2%, P0.05). The 3-year survival rate of treatment group 1 was significantly higher than those of treatment group 2, and control group (71.1% vs. 50.0%, and 45.6%, P0.05). Occurrence of liver metastasis was significantly lower in treatment groups 1 and 2 than in control group (7.7%, and 10.2% vs. 27.3%, P0.05).Combined therapy of intraoperative hypotonic chemo-hyperthermia and early postoperative intraperitoneal chemotherapy is effective for gastric cancer. Intraperitoneal chemotherapy can be used to prevent postoperative liver metastasis of gastric cancer. |
| Databáze: | OpenAIRE |
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