| Autor: |
Pierre-Nicolas, d'Halluin, Bruno, Turlin, Elisabeth, Polard, Michel, Dinasquet, Maël, Pagenault, Nathalie, Rioux, Michel, Gosselin, Jean-François, Bretagne, Denis, Heresbach |
| Jazyk: |
francouzština |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Gastroenterologie clinique et biologique. 27(10) |
| ISSN: |
0399-8320 |
| Popis: |
Non-steroidal anti-inflammatory drugs (NSAIDs) reduce prostaglandin synthesis by inhibiting cyclo-oxygenase 1 (COX-1) and/or cyclo-oxygenase 2 (COX-2). Different groups of NSAIDs, defined by their action on either COX-1 or COX-2, have been developed. Whether intestinal toxicity of preferential or selective COX-2 inhibitors is reduced compared with that of standard NSAIDs is controversial. We report the cases of two patients with self-limited colitis induced by preferential COX-2. We discuss the mechanisms of intestinal toxic effects of COX-2 preferential inhibitors from endoscopic and histological features of colitis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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