Downregulation of antigen-presenting cells in tonsil and lymph nodes of porcine reproductive and respiratory syndrome virus-infected pigs
| Autor: | I M, Rodríguez-Gómez, J, Gómez-Laguna, I, Barranco, F J, Pallarés, G, Ramis, F J, Salguero, L, Carrasco |
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| Rok vydání: | 2012 |
| Předmět: |
B-Lymphocytes
Swine Macrophages T-Lymphocytes Palatine Tonsil Sus scrofa Mediastinum Porcine Reproductive and Respiratory Syndrome Antigen-Presenting Cells Down-Regulation HLA-DR Antigens Immunohistochemistry Animals Pharynx Porcine respiratory and reproductive syndrome virus Lymph Nodes Lymphocyte Count Antigens Viral |
| Zdroj: | Transboundary and emerging diseases. 60(5) |
| ISSN: | 1865-1682 |
| Popis: | Porcine reproductive and respiratory syndrome virus (PRRSV) can persist in different organs of infected pigs, which suggests a failure in the immune response. Antigen-presenting cells (APCs) play a pivotal role in the induction of effective T- and B-cell responses. In this study, we investigated the changes in the different APC subpopulations and T- and B-cell counts in the tonsil, retropharyngeal and mediastinal lymph nodes of pigs experimentally infected with a European PRRSV field isolate. Our results demonstrated that the expression of S100, SWC3, HLA-DR molecule and CD3 was diminished in the studied organs throughout the study, observing a significant negative correlation between viral antigen and HLA-DR expression in both retropharyngeal and mediastinal lymph nodes. In contrast, λ-light chains showed an increase during the study. Taking all into account, after PRRSV infection, no enhancement in the number of APCs and T cells was observed, suggesting an impairment of the immune function which may allow the persistence of PRRSV into the organism. |
| Databáze: | OpenAIRE |
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