Interference of PR3-ANCA with the enzymatic activity of PR3

Autor:	Rarok, AA, van der Geld, YM, Tool, ATJ, de Haas, M, Limburg, PC, Kallenberg, CGM, Roos, D
Jazyk:	angličtina
Rok vydání:	2002
Předmět:	B-Lymphocytes B cell Genes Immunoglobulin sequence analysis DNA Mutational Analysis Autoantigens Autoimmune Diseases immunoglobulin genes Meeting Abstract Commentary Animals Humans Gene Rearrangement B-Lymphocyte development autoantibody Antibody Diversity Autoantibodies
Zdroj:	Arthritis Research
ISSN:	1465-9913 1465-9905
Popis:	The role of autoantibodies in the etiology of autoimmune diseases remains unclear. However, an examination of the sequences of these autoantibodies can be informative. Antibody sequences that violate constraints normally imposed during ontogeny and during development point to a failure of regulation. The existence of clonally related sequences indicates that production of these antibodies may frequently be driven by self-antigen. A better understanding of the mechanisms that normally constrain the composition of the antibody repertoire and of the nature of the inciting and/or driving antigens may yield new insights into both the pathogenesis and potential treatment of these crippling diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5820c30069b7057cd642ca42bc3c61cb http://europepmc.org/articles/PMC3273052 Zobrazit plný text záznamu