| Autor: |
Marlange A, Oliveira, Luana, Heimfarth, Fabiolla Rocha Santos, Passos, Rodrigo, Miguel-Dos-Santos, Moara R, Mingori, José Cláudio F, Moreira, Sandra S, Lauton, Rosana S S, Barreto, Adriano A S, Araújo, Aldeidia P, Oliveira, Júlia T, Oliveira, Abrahao Fontes, Baptista, Ana Maria B, Martinez, Lucindo J, Quintans-Júnior, Jullyana S S, Quintans |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Life sciences. 241 |
| ISSN: |
1879-0631 |
| Popis: |
Peripheral nerve injuries are common conditions that often lead to dysfunctions. Although much knowledge exists on the several factors that mediate the complex biological process involved in peripheral nerve regeneration, there is a lack of effective treatments that ensure full functional recovery. Naringenin (NA) is the most abundant flavanone found in citrus fruits and it has promising neuroprotective, anti-inflammatory and antioxidant effects. This study aimed to enhance peripheral nerve regeneration using an inclusion complex containing NA and hydroxypropyl-β-cyclodextrin (HPβCD), named NA/HPβCD. A mouse sciatic nerve crush model was used to evaluate the effects of NA/HPβCD on nerve regeneration. Sensory and motor parameters, hyperalgesic behavior and the sciatic functional index (SFI), respectively, improved with NA treatment. Western blot analysis revealed that the levels of p75 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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