Rational use of antibiotics in an intensive care unit: a retrospective study of the impact on clinical outcomes and mortality rate

Autor: Muhammad, Ali, Humaira, Naureen, Muhammad Haseeb, Tariq, Muhammad Junaid, Farrukh, Abubakar, Usman, Shahana, Khattak, Hina, Ahsan
Rok vydání: 2019
Předmět:
Zdroj: Infection and Drug Resistance
ISSN: 1178-6973
Popis: Background Intensive care units (ICUs) are specialized units where patients with critical conditions are admitted for getting specialized and individualized medical treatment. High mortality rates have been observed in ICUs, but the exact reason and factors affecting the mortality rates have not yet been studied in the local population in Pakistan. Aim This study was aimed to determine rational use of antibiotic therapy in ICU patients and its impact on clinical outcomes and mortality rate. Methods This was a retrospective, longitudinal (cohort) study including 100 patients in the ICU of the largest tertiary care hospital of the capital city of Pakistan. Results It was observed that empiric antibiotic therapy was initiated in 68% of patients, while culture sensitivity test was conducted for only 19% of patients. Thirty-percent of patients developed nosocomial infections and empiric antibiotic therapy was not initiated for those patients (P
Databáze: OpenAIRE