Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes

Autor:	Patrick, Lugenbiel, Katharina, Govorov, Pascal, Syren, Ann-Kathrin, Rahm, Teresa, Wieder, Maximilian, Wunsch, Nadine, Weiberg, Emili, Manolova, Dominik, Gramlich, Rasmus, Rivinius, Daniel, Finke, Lorenz H, Lehmann, Patrick A, Schweizer, Derk, Frank, Fadwa A, El Tahry, Claus, Bruehl, Tanja, Heimberger, Steffi, Sandke, Tanja, Weis, Patrick, Most, Bastian, Schmack, Arjang, Ruhparwar, Matthias, Karck, Norbert, Frey, Hugo A, Katus, Dierk, Thomas
Rok vydání:	2020
Předmět:	Adult Male Potassium Channels Time Factors Sus scrofa Action Potentials Histone Deacetylase 2 Atrial Remodeling Middle Aged Cell Line Epigenesis Genetic Repressor Proteins Disease Models Animal Heart Rate Case-Control Studies Atrial Fibrillation Animals Humans Female Myocytes Cardiac Heart Atria Aged
Zdroj:	Basic research in cardiology. 116(1)
ISSN:	1435-1803
Popis:	Atrial fibrillation (AF) is associated with electrical remodeling, leading to cellular electrophysiological dysfunction and arrhythmia perpetuation. Emerging evidence suggests a key role for epigenetic mechanisms in the regulation of ion channel expression. Histone deacetylases (HDACs) control gene expression through deacetylation of histone proteins. We hypothesized that class I HDACs in complex with neuron-restrictive silencer factor (NRSF) determine atrial K
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::580131517b068852c2d97b6383dcdf20 https://pubmed.ncbi.nlm.nih.gov/33630168 Zobrazit plný text záznamu Full text from SpringerLink