| Autor: |
K, Yoshidome, M A, Shibata, I G, Maroulakou, M L, Liu, C L, Jorcyk, L G, Gold, V N, Welch, J E, Green |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
International journal of oncology. 12(2) |
| ISSN: |
1019-6439 |
| Popis: |
We have generated a transgenic mouse model in which female mice develop ductal mammary adenocarcinomas and male mice develop prostatic adenocarcinomas by using a transgene containing the hormone-responsive rat prostatic steroid binding protein 5' flanking region C3(1) fused to the simian virus 40 (SV40) large T antigen. We have identified some genetic alterations during mammary and prostate tumor progression: (i) p53 is functionally inactivated during mammary cancer development without p53 mutations; (ii) Alterations in apoptosis during mammary tumor progression are p53 and bcl-2 independent; (iii) Ha-ras mutations occur early in the development of prostate cancer. This unique animal model offers the opportunity to study multistep tumorigenesis in these organs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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