| Autor: |
Zheng-xiao, Li, Zhen-hui, Peng, Fan-pu, Ji, Jing-yi, Yuan, Min, Pan, Yan, Liu, Qiong, Wang |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 26(8) |
| ISSN: |
1673-4254 |
| Popis: |
To investigate the involvement of E-cadherin-catenin adhesion system in Bowen's disease (BD) and cutaneous squamous cell carcinoma (SCC).Fifteen normal skin, 28 BD and 18 SCC specimens were stained with monoclonal antibodies against E-cadherin and beta-catenin. Evaluation of the staining results was performed with semi-quantification of the pattern and intensity of staining, percentage of positive cells, and cytoplasmic staining.Normal skins strongly expressed membranous E-cadherin and beta-catenin, but their expression was remarkably reduced in BD and SCC. Abnormal staining of beta-catenin was observed in the cytoplasm or cell nuclei of BD and SCC.Abnormal expression of the E-cadherin/catenin complex is common in SCC and BD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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