[Antigen-specific and antigen-nonspecific reactions of the immunity system in vaccination with a purified concentrated staphylococcal anatoxin]

Autor: A M, Katkhanov, O V, Borovikov, V Ia, Prokhorov, G L, Ratgauz, I V, Vasil'eva
Rok vydání: 1987
Předmět:
Zdroj: Zhurnal mikrobiologii, epidemiologii i immunobiologii. (3)
ISSN: 0372-9311
Popis: Immunization with purified and concentrated staphylococcal toxoid leads to the rapid 12-fold rise of the level of anti-alpha-toxin and to the 17-fold rise of the titres of antibodies to extracellular staphylococcal products. At the period of immunization phasic changes in cell-mediated and humoral immunity characteristics, indicative of the state of the nonspecific resistance system, can be observed. These changes consist in the transient suppression of phagocytosis, including a decrease in the activity of intraleukocytic bactericidal systems (myeloperoxidase and cation protein), a decrease in the activity of the complement and the bactericidal activity of the blood serum, which should be taken into account when using this immune preparation for therapy.
Databáze: OpenAIRE