| Autor: |
E, Algün, C, Topal, M, Oztürk, M Ramazan, Sekeroğlu, A, Durmuş |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
International journal of clinical practice. 58(3) |
| ISSN: |
1368-5031 |
| Popis: |
Hypothyroidism is associated with a number of functional renal disorders primarily affecting water and salt handling. In this study, we aim to investigate functional renal disorders in overt and subclinical hypothyroidism. We utilised urinary beta-2 microglobulin (beta2M) as a sensitive marker of tubular dysfunction. Urinary beta2M excretion and tests for renal functions were repeated before and after T4 replacement therapy. Forty-four patients (28 with overt disease, 16 with subclinical disease) and 31 healthy control subjects were involved in the study. There was a significant increase in urinary beta2M in both overt and subclinical hypothyroidism (p0.05 in both). TSH levels were correlated with beta2M excretion. Effects of hypothyroidism on renal functions were readily reversible by 3 weeks of thyroid hormone replacement therapy. Urinary beta2M was a sensitive marker of renal tubular dysfunction associated with overt and subclinical hypothyroidism. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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