Design driven HtL: The discovery and synthesis of new high efficacy β₂-agonists

Autor:	Michael J, Stocks, Lilian, Alcaraz, Andrew, Bailey, Roger, Bonnert, Elaine, Cadogan, Jadeen, Christie, Stephen, Connolly, Anthony, Cook, Adrian, Fisher, Alice, Flaherty, Stephen, Hill, Alexander, Humphries, Anthony, Ingall, Stephen, Jordan, Mandy, Lawson, Alex, Mullen, David, Nicholls, Stuart, Paine, Garry, Pairaudeau, Stephen, St-Gallay, Alan, Young
Rok vydání:	2011
Předmět:	Models Molecular Structure-Activity Relationship Molecular Structure Drug Design Animals Humans Bronchi Crystallography X-Ray Adrenergic beta-2 Receptor Agonists Cell Line
Zdroj:	Bioorganicmedicinal chemistry letters. 21(13)
ISSN:	1464-3405
Popis:	The design and synthesis of a new series of high efficacy β(2)-agonists devoid of the key benzylic alcohol present in previously described highly efficacious β(2)-agonists is reported. A hypothesis for the unprecedented level of efficacy is proposed based on considerations of β(2)-adrenoceptor crystal structure, other biophysical data and modeling studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::57ab5c3fc51d764d7315a582ff12de6f https://pubmed.ncbi.nlm.nih.gov/21652207 Zobrazit plný text záznamu Full Text from ScienceDirect