| Autor: |
Swati, Mishra, Philip R, Streeter |
| Rok vydání: |
2022 |
| Zdroj: |
Methods in molecular biology (Clifton, N.J.). 2592 |
| ISSN: |
1940-6029 |
| Popis: |
Innovations in the field of amphiphilic block copolymers have led to the development of a series of attractive polymer-based drug and gene delivery micellar formulations. The amphiphilic block copolymers' low critical micelle concentration (CMC) results in highly stable nanoscale micelles possessing favorable in vivo safety profiles and biocompatibility, making them an excellent carrier choice for the systemic administration of various poorly soluble drugs. These micelles can also be used as an actively targeted drug delivery system. The targeting is achieved by conjugating specific targeting ligand molecules to the micelle surface. The conjugation takes place at the hydrophilic termini of the copolymers, which forms the shell or surface of the nanomicelles. In our lab, we have developed a targeted Pluronic |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
