| Popis: |
The stability of extemporaneously compounded testosterone sterile solution in large-volume parenterals (LVPs) in plastic bags containing 0.9% sodium chloride solution was evaluated. Two LVPs were prepared; one remained at room temperature and the other was refrigerated. Samples were withdrawn and frozen at 0, 1, 3, 6, 9 and 24 hours. The concentrations of the samples at each time point were determined using a specific radioimmunoassay. Stability was defined as 90% or greater of the original concentration remaining. No color change was observed at any time during hte study. Inravenous testosterone solutions compounded extemporaneously in 0.9% sodium chloride solution containing LVPs in plastic bags were stable for nine hours at 5 deg C but were unstable at 24 deg C after only one hour. |
