RUNX1 and TGF-β signaling cross talk regulates Ca

Autor:	Sanjeev, Raghuwanshi, Swati, Dahariya, Durga Shankar, Sharma, Narasaiah, Kovuru, Itishri, Sahu, Ravi Kumar, Gutti
Rok vydání:	2020
Předmět:	Transforming Growth Factor beta1 Gene Expression Regulation Core Binding Factor Alpha 2 Subunit Humans Calcium Cell Differentiation Calcium Channels Hematopoietic Stem Cells Megakaryocytes Signal Transduction
Zdroj:	The FEBS journalReferences. 287(24)
ISSN:	1742-4658
Popis:	Thrombocytopenia is characterized by low platelet count and is typically observed among all preterm and low birthweight neonates admitted to the neonatal intensive care unit. Although the underlying cause for this predisposition is unclear, recent studies have proposed that the intrinsic inability of neonatal hematopoietic stem/progenitor cells to produce mature polyploid megakaryocytes (MKs) may result in delayed platelet engraftment. The developmental and molecular differences between neonatal and adult MKs are not yet fully understood. Previously, we had reported that the key MK transcription factor RUNX1, which is crucial for the regulation of MK specification and maturation, is down-regulated in neonatal MKs when compared with adult MKs. In humans, loss-of-function mutations in RUNX1 cause familial platelet disorder, which is characterized by thrombocytopenia, indicating its crucial role in MK development. However, information about its cross talk with developmentally regulated signaling pathways in MKs is lacking. In this study, we performed a differential gene expression analysis in MKs derived from human cord blood (CB) and adult peripheral blood (PB) CD34
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5786e030b742d571a80657ec51a50edb https://pubmed.ncbi.nlm.nih.gov/32281291 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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