| Autor: |
R J, Jackson, D J, Maguire, L A, Hinds, I A, Ramshaw |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
Biology of reproduction. 58(1) |
| ISSN: |
0006-3363 |
| Popis: |
Population control has become a major problem in many wildlife species. Fertility control through immunocontraception has been proposed as a method for reducing population size. We have tested the concept that immunocontraception can be achieved with a recombinant ectromelia virus expressing an ovary-specific antigen, the mouse zona pellucida 3 (ZP3) glycoprotein. Female mice infected with the recombinant virus produced autoimmune antibodies against ZP3 and were infertile for 5-9 mo after infection. For almost half the infertile mice, immunity to ZP3 was associated with a disruption of ovarian follicular development and the depletion of mature follicles without observable oophoritis. Mice returned to fertility as the anti-ZP3 antibody level in the serum decreased. Reinfection of the mice with the recombinant virus boosted the anti-ZP3 response and restored infertility. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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