| Autor: |
Elżbieta, Kublin, Krystyna, Czerwińska, Elżbieta, Wyszomirska, Anna, Zajaczkowską, Ewa, Malanowicz, Barbara, Kaczmarska-Graczyk, Aleksander P, Mazurek |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Acta poloniae pharmaceutica. 72(2) |
| ISSN: |
0001-6837 |
| Popis: |
Benazepril hydrochloride contains two stereogenic centers, but is currently available as single enantiomer (S,S configuration) for the treatment of hypertension. Its enantiomer (R,R configuration) and the diastereoisomeric pair (R,S and S,R) can be regarded as impurities. Stereochemical stability of S,S isomer of benazepril hydrochloride and its potential susceptibility to conversion in the.active substance and in Lisonid tablets were examinated. The separation with the use of the TLC method with the following system: chromatographic plates Chiralplate and a mobile phase: methanol - acetonitrile - 1 mM copper(II) acetate (4 : 2 : 4, v/v/v) with saturation of glacial acetic acid for 1 h and the HPLC method system: Chiral AGP column (150 x 4.0 man x 5 µm) and a mobile phase: phosphate buffer pH = 6.0 - methanol (80 : 20, v/v) were obtained. Active substance - benazepril hydrochloride and Lisonid tablets 20 mg were subjected to the impact of different stress factors. Samples were examined after 1 and 6 weeks. It was found that none of the applied stress factors caused the transformation of the S,S enantiomer of benazepril hydrochloride in the substance and tablets to other identified stereoisomers - only the compound decomposition has occurred. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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