Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder

Autor:	Hanna, Järnum, Simon F, Eskildsen, Elena G, Steffensen, Søren, Lundbye-Christensen, Carsten W, Simonsen, Ib S, Thomsen, Ernst-Torben, Fründ, Jean, Théberge, Elna-Marie, Larsson
Rok vydání:	2011
Předmět:	Adult Cerebral Cortex Male Psychiatric Status Rating Scales Brain Mapping Depressive Disorder Major Neurotransmitter Agents Biological Availability Middle Aged Magnetic Resonance Imaging Synaptic Transmission Antidepressive Agents Perfusion International Classification of Diseases Risk Factors Limbic System Humans Female Cerebrospinal Fluid
Zdroj:	Acta psychiatrica Scandinavica. 124(6)
ISSN:	1600-0447
Popis:	To determine whether patients with major depressive disorder (MDD) display morphologic, functional, and metabolic brain abnormalities in limbic-cortical regions at a baseline magnetic resonance (MR) scan and whether these changes are normalized in MDD patients in remission at a follow-up scan.A longitudinal 3.0-Tesla (T) magnetic resonance imaging (MRI) study was carried out with cortical thickness measurements with a surface-based approach, perfusion measurements with three-dimensional (3D) pseudo-continuous arterial spin labeling (pCASL), and spectroscopy (1H-MRS) measurements in the anterior cingulate cortex (ACC) with water as an internal reference adjusted for cerebrospinal fluid content. We examined 23 MDD patients and 26 healthy controls. MDD patients underwent a baseline MRI at inclusion and were invited to a follow-up scan when they were in remission or after a 6-month follow-up period.Major findings were a significantly thinner posterior cingulate cortex in non-remitters than in remitters, a significant decrease in perfusion in the frontal lobes and the ACC in non-remitters compared with healthy controls at baseline and significantly reduced N-acetylaspartate, myo-inositol, and glutamate levels in MDD patients compared with healthy controls at baseline.Using novel MRI techniques, we have found abnormalities in cerebral regions related to cortical-limbic pathways in MDD patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::56e503a98200062859406f8bfa2b09b3 https://pubmed.ncbi.nlm.nih.gov/22077847 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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