[Anti-CD4 autoimmunity in HIV-infected persons in Russia]
| Autor: | L F, Lideman, E V, Kasennova, G F, Denisova, V M, Stakhanova, S Ia, Zverev, R A, Gibadulin, A F, Bobkov |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Human Immunodeficiency Virus Proteins Molecular Sequence Data Epitopes T-Lymphocyte HIV Infections Gene Products nef Species Specificity CD4 Antigens Consensus Sequence HIV-1 Humans Female Viral Regulatory and Accessory Proteins Amino Acid Sequence nef Gene Products Human Immunodeficiency Virus Substance Abuse Intravenous Autoantibodies |
| Zdroj: | Voprosy virusologii. 50(5) |
| ISSN: | 0507-4088 |
| Popis: | The frequency of anti-CD4 antibodies was determined in the sera or plasma derived from the patients infected with HIV-1 belonging to different genetic subgroups. The anti-CD4-antibodies in a dilution ofor = 1:1000 were found in 14% of the patients infected with the gagA/envA virus characteristic for injectable drug users in East Europe. The frequency of autoimmune antibodies among the HIV-infected patients with envB virus was substantially less (4.4%). Competitive ELISA using monoclonal antibodies to different CD4 domains demonstrated that irrespective of the viral genotype, the autoimmune epitope is located within the D4 or D3/D4 domains of CD4 receptor. |
| Databáze: | OpenAIRE |
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