| Autor: |
Ni, Dai, Si-Qin, Huang, Cheng-Lin, Tang, Cheng-Fang, Tan, Pan, Dai, Ting-Ting, Zeng, Zheng-Wei, Zhu, Zhi-Xue, Yang |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Zhen ci yan jiu = Acupuncture research. 44(11) |
| ISSN: |
1000-0607 |
| Popis: |
To observe the effect of electroacupuncture (EA) on the expression of apolipoprotein E (ApoE) and related proteins of inflammation and anti-oxidative stress in spinal cord in mice with spinal cord injury (SCI), so as to explore its mechanisms underlying function repair.Thirty-six female C57BL/6 mice were equally randomized into 3 groups: sham operation, model and EA. The SCI model was established by clamping the spinal cord for 25 s with a serrefine after laminectomy of the 1After modeling, the BMS scores were significantly decreased in the model group compared with the sham operation group (EA can significantly improve locomotor function in SCI mice, which is associated with its effects in reducing inflammation, oxi-dative stress reactions and reactive astrocyte proliferation via up-regulating expression of ApoE, p-ERK1/2, and Nrf2/HO-1 (antioxidant pathway) and inhibiting IL-1β and NF-κB expression. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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