| Autor: |
Chen, Zhu, Qing-Yu, Weng, Ling-Ren, Zhou, Chao, Cao, Fei, Li, Yin-Fang, Wu, Yan-Ping, Wu, Miao, Li, Yue, Hu, Jia-Xin, Shen, Xue-Fang, Xiong, Fen, Lan, Li-Xia, Xia, Bin, Zhang, Hao, Zhang, Man, Huang, Song-Min, Ying, Hua-Hao, Shen, Zhi-Hua, Chen, Wen, Li |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
The European respiratory journal. 56(5) |
| ISSN: |
1399-3003 |
| Popis: |
Acute lung injury (ALI) is a fatal but undertreated condition with severe neutrophilic inflammation, although little is known about the functions of eosinophils in the pathogenesis of ALI. Our objectives were to investigate the roles and molecular mechanisms of eosinophils in ALI.Pulmonary eosinophils were identified by flow cytometry. Mice with abundant or deficient eosinophils were used. Cellularity of eosinophils and neutrophils in bronchoalveolar lavage fluid, inflammatory assessment, and survival rate were determined. Human samples were also used for validating experimental results.Blood eosinophils were increased in surviving patients with acute respiratory distress syndrome (ARDS) independent of corticosteroid usage. There existed homeostatic eosinophils in lung parenchyma in mice and these homeostatic eosinophils, originating from the bone marrow, were predominantly CD101Collectively, our findings identify an uncovered function of native CD101 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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