| Autor: |
Chen, Aoshuang, Geng, Yajun, Ke, Hanzhong, Constant, Laura, Yan, Zhaoqi, Pan, Yue, Lee, Patricia, Tan, Isaiah, Williams, Kurt, George, Samantha, Gnanasekar, Munirathinam, Reardon, Catherine A., Getz, Godfrey S., Wang, Bin, Zheng, Guoxing |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Popis: |
The immunosuppressant dexamethasone was previously shown to preferentially deplete CD4+ Teff cells while sparing Treg cells in vivo. In the present study, we show that it also preferentially depletes B-2 cells while sparing B-1 cells. In the ApoE−/− mouse model of atherosclerosis, where both Treg and B-1 cells are thought to play an atheroprotective role, we show that HSP60-targeted immunization in the presence of dexamethasone raises Ag-reactive Treg and B-1 cells concomitantly and reduces the severity of atherosclerosis. These results indicate that dexamethasone is an adjuvant that potentiates both the Treg and the B-1 responses to immunogens. This study shows for the first time that B-1 cells with the specificity for a disease-relevant Ag can be raised in vivo by immunization. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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