Polymorphism of the human retinoid X receptor beta and linkage disequilibrium with HLA-DPB1
| Autor: | R, Rajsbaum, D, Fici, P A, Fraser, P O, Flores-Villanueva, Z L, Awdeh |
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| Rok vydání: | 2001 |
| Předmět: |
Male
HLA-DP Antigens Polymorphism Genetic Receptors Retinoic Acid Histocompatibility Testing Sequence Analysis DNA Polymerase Chain Reaction Linkage Disequilibrium Pedigree Retinoid X Receptors Gene Frequency Humans Female Alleles HLA-DP beta-Chains Polymorphism Restriction Fragment Length Transcription Factors |
| Zdroj: | Tissue antigens. 58(1) |
| ISSN: | 0001-2815 |
| Popis: | The human retinoid X receptor beta (RXRB) gene is localized in the major histocompatibility complex (MHC) region between DPB1 and RING2. The RXRB gene sequence reported by different investigators suggests that the gene may be polymorphic. In this study, we confirmed one polymorphism by sequencing genomic DNA from four Caucasian individuals. We also developed a restriction fragment length polymorphism (RFLP) analysis to detect this specific polymorphism. Linkage analysis studies between RXRB alleles and a number of HLA markers showed significant linkage disequilibrium between RXRB*T and HLA-DPB1*0401. |
| Databáze: | OpenAIRE |
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