| Autor: |
Anna, Pućkowska, Danuta, Drozdowska, Krystyna, Midura-Nowaczek |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Acta poloniae pharmaceutica. 64(2) |
| ISSN: |
0001-6837 |
| Popis: |
A DNA-binding affinity and the effect on restriction enzymes activity of seven carbocyclic mono- and bis-lexitropsins and two analogues of pentamidine with unsubstituted N-terminal amine group were investigated. DNA association constants (Kapp) show that DNA affinity of mono-compounds is much weaker than netropsin and distamycin. Bis-analogues of netropsin bind DNA more strongly than mono-ligands, but without sequence-selectivity. Only pentamidine derivatives reveal preference to AT-rich sequence. The studied compounds can inhibit catalytical action of endonucleases recognizing sequence of four AT base pairs following one another. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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