| Autor: |
Paulina, Sander, Michael, Feng, Maria K, Schweitzer, Fabiola, Wilting, Sophie M, Gutenthaler, Daniela M, Arduino, Sandra, Fischbach, Lisa, Dreizehnter, Alessandra, Moretti, Thomas, Gudermann, Fabiana, Perocchi, Johann, Schredelseker |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
British journal of pharmacologyREFERENCES. 178(22) |
| ISSN: |
1476-5381 |
| Popis: |
Treatment of cardiac arrhythmia remains challenging due to severe side effects of common anti-arrhythmic drugs. We previously demonstrated that mitochondrial CaHerewe screened 727 compounds with a history of use in human clinical trials in a three-step screening approach. As a primary screening platform we used a permeabilized HeLa cell-based mitochondrial CaWe identifiedtwo candidate compounds, the clinically approved drugs ezetimibe and disulfiram, which stimulate SR-mitochondria CaTaken together we identified ezetimibe and disulfiram as novel MiCUps and efficient suppressors of arrhythmogenesis and as such as, promising candidates for future preclinical and clinical studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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