| Autor: |
Amanda, Berg, Chelsea B, Swartchick, Noah, Forrest, Matthew, Chavarria, Madeleine C, Deem, Alyson N, Sillin, Yuexin, Li, Teresa M, Riscoe, Aaron, Nilsen, Michael K, Riscoe, Warren Jl, Wood |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Future medicinal chemistry. 14(22) |
| ISSN: |
1756-8927 |
| Popis: |
Malaria is a disease caused by a parasite that affects millions of people each year and results in many deaths. In 1948, 300 structurally related compounds were made and tested for antimalarial activity with the goal of finding a drug to treat the disease. From this work, promising compounds were identified and this work has served as a starting point for further investigations. Based on recent discoveries, this study made variations of promising 1948 compounds to investigate whether antimalarial activity could be improved. These compounds were made using two different methods. One derivative was found to be more potent than the original compound but was not the one expected based on the 1948 work. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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