Phosphatidylinositol 4,5-bisphosphate (PIP

Autor:	Matthew K, Kirchner, Robert C, Foehring, Lie, Wang, Giri Kumar, Chandaka, Joseph C, Callaway, William E, Armstrong
Rok vydání:	2017
Předmět:	Androstadienes Neurons Phosphatidylinositol 4 5-Diphosphate Rats Sprague-Dawley Neuroscience ‐ Cellular/Molecular Action Potentials Animals lipids (amino acids peptides and proteins) Female In Vitro Techniques Oxytocin Wortmannin Supraoptic Nucleus
Zdroj:	The Journal of physiology. 595(14)
ISSN:	1469-7793
Popis:	Afterhyperpolarizations (AHPs) generated by repetitive action potentials in supraoptic magnocellular neurons regulate repetitive firing and spike frequency adaptation but relatively little is known about PIP2’s control of these AHPs.We examined how changes in PIP2 levels affected AHPs, somatic [Ca2+]i, and whole cell Ca2+ currents.Manipulations of PIP2 levels affected both medium and slow AHP currents in oxytocin (OT) neurons of the supraoptic nucleus.Manipulations of PIP2 levels did not modulate AHPs by influencing Ca2+ release from IP3‐triggered Ca2+ stores, suggesting more direct modulation of channels by PIP2.PIP2 depletion reduced spike‐evoked Ca2+ entry and voltage‐gated Ca2+ currents.PIP2 appears to influence AHPs in OT neurons by reducing Ca2+ influx during spiking.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::56219f16d6a6f5ecf095cc50028eb14d https://pubmed.ncbi.nlm.nih.gov/28383826 Zobrazit plný text záznamu Plný text