| Autor: |
J R, Dimmock, E, Erciyas, S K, Raghavan, D L, Kirkpatrick |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Die Pharmazie. 45(10) |
| ISSN: |
0031-7144 |
| Popis: |
1-Phenyl-3-(4-morpholinyl)propan-1-one hydrochloride 1 and the related piperidino derivative 2 were shown to have activity against the EMT6 tumour in vitro. Modification of the structures of these compounds by introducing a glucosyloxy group onto the aryl rings lowered cytotoxicity but conversion of 1 and 2 into the corresponding bis-Mannich bases increased bioactivity considerably. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
