Patterns of response to acute naloxone infusion in Tourette's syndrome

Autor:	P J, van Wattum, P B, Chappell, D, Zelterman, L D, Scahill, J F, Leckman
Rok vydání:	2000
Předmět:	Adult Male Treatment Outcome Dose-Response Relationship Drug Double-Blind Method Naloxone Narcotic Antagonists Tic Disorders Receptors Opioid Humans Middle Aged Drug Administration Schedule Tourette Syndrome
Zdroj:	Movement disorders : official journal of the Movement Disorder Society. 15(6)
ISSN:	0885-3185
Popis:	The purpose of this study was to replicate findings from an earlier pilot study in which we found a dose-related effect of the opioid antagonist naloxone on tic behavior in patients with Tourette's syndrome (TS). Fifteen subjects with TS were challenged with randomized doses (30 and 300 microg/kg) of naloxone at 3-day intervals. Videotaped recordings of tic behavior were counted in a "blind" fashion. We found that naloxone had opposite effects on tics at different dosages. The low dose caused a significant decrease in tics, whereas the high dose caused a significant increase in tics. Therefore, activity at opioid receptors appears to influence the expression of TS, and the difference in response to naloxone in TS subjects may be based on a dose-response effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::55e9052b6ed5cccb304b325b49743cc3 https://pubmed.ncbi.nlm.nih.gov/11104215 Zobrazit plný text záznamu Plný text