| Autor: |
Przemyslaw, Rys, Sebastian, Borys, Jerzy, Hohendorff, Aleksandra, Zapala, Przemyslaw, Witek, Magdalena, Monica, Claudia, Frankfurter, Agnieszka, Ludwig-Slomczynska, Beata, Kiec-Wilk, Maciej T, Malecki |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Endocrine. 68(1) |
| ISSN: |
1559-0100 |
| Popis: |
Negative-pressure wound therapy (NPWT) is an adjunct modality in diabetic foot ulcerations (DFUs). Randomized controlled trials (RCTs) have shown its advantage over standard approaches; however, data from observational studies remain scarce.We performed a systematic review of observational non-RCTs evaluating NPWT efficacy and safety in patients with DFU.Electronic databases were searched for observational studies involving NPWT. The results of single-arm studies were presented as percentages of patients with the outcome of interest. A meta-analysis of comparative studies provided point estimates of outcomes. Continuous outcomes were reported as either weighted or standardized mean differences and dichotomous data as relative risks (RR).The search identified 16 relevant observational studies, 12 single-arm, and 4 comparative, reporting on a total of 18,449 patients with DFU, of whom 1882 were managed with NPWT. In the NPWT-treated patients, ulcers were larger (average size range 6.6-27.9 cmThis systematic review of observational studies provided supportive evidence that NWPT is an efficient and safe adjunct treatment in the management of DFUs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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