| Autor: |
K J, Kazmierski, G K, Ogilvie, M J, Fettman, S E, Lana, J A, Walton, R A, Hansen, K L, Richardson, D W, Hamar, C L, Bedwell, G, Andrews, S, Chavey |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Journal of veterinary internal medicine. 15(6) |
| ISSN: |
0891-6640 |
| Popis: |
We compared serum concentrations of zinc, chromium, and iron in dogs with cancer to those of normal dogs. Dogs with lymphoma (n = 50) and osteosarcoma (n = 52) were evaluated. Dogs with lymphoma had significantly lower (P = .0028) mean serum zinc concentrations (mean +/- SD; 1.0 +/- 0.3 mg/L) when compared to normal dogs (1.2 +/- 0.4 mg/L). Dogs with osteosarcoma also had lower mean serum zinc concentrations (1.1 +/- 0.4 mg/L), but this difference was not significant (P = .075). Serum chromium concentrations were significantly lower in dogs with lymphoma (2.6 +/- 2.6 microg/L, P = .0007) and osteosarcoma (2.4 +/- 3.1 microg/L, P = .0001) compared to normal dogs (4.7 +/- 2.8 microg/L). Serum iron concentrations and total iron-binding capacity were significantly lower in dogs with lymphoma (110.8 +/- 56.7 microg/dL, P.0001, and 236.6 +/- 45.6 microg/dL, P.0001, respectively) and osteosarcoma (99.6 +/- 49.3 microg/dL, P.0001, and 245.0 +/- 43.8 microg/dL, P = .0011, respectively) when compared to normal dogs (175.1 +/- 56.7 microg/dL and 277.1 +/- 47.4 microg/dL). Mean ferritin concentration was significantly higher in dogs with lymphoma (1291.7 +/- 63.0 microg/L) than in normal dogs (805.8 +/- 291.1 microg/L, P.0001) and dogs with osteosarcoma (826.5 +/- 309.2 microg/L, P.0001). Further investigation is needed to explore the clinical significance of these mineral abnormalities in dogs with cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Plný text