HPV16E7-Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3
| Autor: | Paula, Kuo, Zewen K, Tuong, Siok Min, Teoh, Ian H, Frazer, Stephen R, Mattarollo, Graham R, Leggatt |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Graft Rejection
Receptors CXCR3 Papillomavirus E7 Proteins T-Lymphocytes Uterine Cervical Neoplasms Mice Transgenic Chemokine CXCL9 Tissue Culture Techniques Mice Lymphocytes Tumor-Infiltrating Cell Movement Animals Promoter Regions Genetic Immunologic Surveillance Skin Human papillomavirus 16 Hyperplasia Papillomavirus Infections Keratin-14 Skin Transplantation Uterine Cervical Dysplasia Chemokine CXCL10 Mice Inbred C57BL Disease Models Animal Female Tumor Escape |
| Zdroj: | The Journal of investigative dermatology. 138(6) |
| ISSN: | 1523-1747 |
| Popis: | Chemokines regulate tissue immunity by recruiting specific subsets of immune cells. Mice expressing the E7 protein of human papilloma virus 16 as a transgene from a keratin 14 promoter (K14.E7) show increased epidermal and dermal lymphocytic infiltrates, epidermal hyperplasia, and suppressed local immunity. Here, we show that CXCL9 and CXCL10 are overexpressed in non-hematopoietic cells in skin of K14.E7 mice when compared with non-transgenic animals, and recruit CXCR3 |
| Databáze: | OpenAIRE |
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