Ciglitazone, an agonist of peroxisome proliferator-activated receptor gamma, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin

Autor:	Piotr, Mrówka, Eliza, Glodkowska, Dominika, Nowis, Magdalena, Legat, Tadeusz, Issat, Marcin, Makowski, Angelika, Szokalska, Sylwia, Janowska, Tomasz, Stoklosa, Marek, Jakóbisiak, Jakub, Golab
Rok vydání:	2007
Předmět:	PPAR gamma Mice Cell Line Tumor Intracellular Signaling Peptides and Proteins Animals Humans Antineoplastic Agents Drug Synergism Thiazolidinediones Lovastatin Hydroxymethylglutaryl-CoA Reductase Inhibitors Cyclin-Dependent Kinase Inhibitor p27
Zdroj:	International journal of oncology. 32(1)
ISSN:	1019-6439
Popis:	Thiazolidinediones are ligands of PPAR-gamma, a member of the nuclear receptor family. These drugs have shown promising pre-clinical activity in tumor models but clinical studies failed to confirm their beneficial effect. We have studied the in vitro antitumor effects of a combination of ciglitazone, a thiazolidinedione drug, and lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. We observed a marked synergism in several different tumor cell lines resulting from both inhibition of cell proliferation and induction of apoptosis. These results strongly suggest that combining PPAR-gamma agonists with statins can produce significant antitumor effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::55a1b1e496f2a53c2250c8cd0f73b3ff https://pubmed.ncbi.nlm.nih.gov/18097565 Zobrazit plný text záznamu