| Autor: |
Simon A, Sharples, Jessica, Parker, Alex, Vargas, Jonathan J, Milla-Cruz, Adam P, Lognon, Ning, Cheng, Leanne, Young, Anchita, Shonak, Gennady S, Cymbalyuk, Patrick J, Whelan |
| Rok vydání: |
2021 |
| Zdroj: |
Frontiers in cellular neuroscience. 15 |
| ISSN: |
1662-5102 |
| Popis: |
Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns of rhythmic activity. Variation in excitability state and neuromodulatory tone can facilitate transitions between episodic and continuous rhythms; however, the intrinsic mechanisms that govern these rhythms and their transitions are poorly understood. Here, we tested the capacity of a single central pattern generator (CPG) circuit with tunable properties to generate multiple outputs. To address this, we deployed a computational model composed of an inhibitory half-center oscillator (HCO). Following predictions of our computational model, we tested the contributions of key properties to the generation of an episodic rhythm produced by isolated spinal cords of the newborn mouse. The model recapitulates the diverse state-dependent rhythms evoked by dopamine. In the model, episodic bursting depended predominantly on the endogenous oscillatory properties of neurons, with Na |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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