Investigating the Influence of Tablet Location Inside Dissolution Test Apparatus on Polymer Erosion and Drug Release of a Surface-Erodible Sustained-Release Tablet Using Computational Simulation Methods

Autor:	Hao, Lou, Michael J, Hageman
Rok vydání:	2021
Předmět:	Drug Liberation Solubility Polymers Delayed-Action Preparations Hydrodynamics Computer Simulation Tablets
Zdroj:	AAPS PharmSciTech. 22(3)
ISSN:	1530-9932
Popis:	The objective of this work was to investigate the influence of tablet location along the bottom of a USP apparatus II vessel on polymer erosion and drug release of surface-erodible sustained-release tablets using computational simulation methods. Computational fluid dynamics (CFD) methods were performed to simulate the velocity distribution. A mathematical model was developed to describe polymer erosion and tablet deformation according to the mass transfer coefficient. Numerical analysis was used to simulate drug release controlled by drug diffusion and polymer erosion. The results indicated that tablets located at the off-center position deformed faster than the tablets located at the center position. However, tablet location had no profound impact on drug release rate since all drug release profiles were "similar" according to the f
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::559285a7953e581999fee71dbcb8fda1 https://pubmed.ncbi.nlm.nih.gov/33709248 Zobrazit plný text záznamu Full text from SpringerLink