| Autor: |
Hui-Juan, Wan, Yang, Wang, Jun-Qiang, Si, Li, Li |
| Rok vydání: |
2017 |
| Zdroj: |
Experimental and therapeutic medicine. 16(4) |
| ISSN: |
1792-0981 |
| Popis: |
The present study aimed to investigate the role of propofol in mediating the vasomotor activity of the mesenteric arteriole (MA) of Sprague Dawley (SD) rats, and to elucidate the underlying mechanisms. The pressure myograph technique was used to examine the effect of different concentrations of propofol on the relaxation of blood vessels in the 2-3 mm MA segments freshly separated from the SD rats. The whole-cell patch-clamp technique was applied to observe the outward current of single vascular smooth muscle cells (VSMCs) obtained from the MAs of the SD rats. Furthermore, immunofluorescence was utilized to assess the expression of connexin (Cx) in the MAs of SD rats. The results indicated the following: i) Propofol relaxed the MA of SD rats in a concentration-dependent manner from 1×10 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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