Chemoenzymatic approach to optically active 4-hydroxy-5-alkylcyclopent-2-en-1-one derivatives: an application of a combined circular dichroism spectroscopy and DFT calculations to assignment of absolute configuration

Autor:	Jadwiga, Frelek, Michał, Karchier, Daria, Madej, Karol, Michalak, Paweł, Różański, Jerzy, Wicha
Rok vydání:	2013
Předmět:	Models Molecular Kinetics Magnetic Resonance Spectroscopy Models Statistical Spectrophotometry Infrared Circular Dichroism Molecular Conformation Spectrophotometry Ultraviolet Stereoisomerism Cyclopentanes Lipase Hydrogen-Ion Concentration Candida
Zdroj:	Chirality. 26(6)
ISSN:	1520-636X
Popis:	A series of representative optically active derivatives of 4-hydroxy-5-alkylcyclopent-2-en-1-one were prepared from the respective 2-furyl methyl carbinols via the Piancatelli rearrangement followed by the enzymatic kinetic resolution of racemates. Applicability of chiroptical methods (experimental and calculated electronic circular dichroism [ECD] and vibrational circular dichroism [VCD] spectra) to determine the absolute configuration of both stereogenic centers in 4-hydroxy-5-methylcyclopent-2-en-1-one was demonstrated. It was also demonstrated that the concurrent application of ECD and VCD spectroscopy can be used for the determination of the configuration of two stereogenic centers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5560e3fe20c4ec36daf77a7830eea20b https://pubmed.ncbi.nlm.nih.gov/24788690 Zobrazit plný text záznamu Plný text