| Autor: |
Maria Lucia Fernandes, Penna, Samira, Buhrer-Sékula, Maria Araci De Andrade, Pontes, Rossilene, Cruz, Heitor De Sá, Gonçalves, Gerson Oliveira, Penna |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Leprosy review. 83(3) |
| ISSN: |
0305-7518 |
| Popis: |
Many believe that the regular treatment for multibacillary (MB) leprosy cases could be shortened. A shorter treatment, allowing for uniform treatment for all cases, makes case classification superfluous and therefore simplifies leprosy control.To evaluate the association of the treatment duration with the frequency of reactions among MB patients.An open-label randomised clinical trial to compare the present routine treatment with one lasting six months. Patients were recruited between March 2007 and February 2012. We analysed the frequency of first reaction with the Kaplan-Meier method and of recurrent reaction with a Poisson regression, using the treatment group and baciloscopic index level (BI) as independent variables. Logistic regression was used to evaluate the statistical association of different reaction types and the treatment group.Among those with BI3, we found a statistical significant difference of reaction frequencies between the treatment groups from 6 to 18 months since the beginning of treatment. This difference disappears at 2 years after the start of treatment. Multiple reactions were associated with the treatment group and with BIor = 3. No specific types of reactions were associated with treatment duration.Although this is the first report of U-MDT/CT-BR, the results presented here support the possibility of use of UMDT in the field. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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