Preclinical biodistribution and dosimetry and human biodistribution comparing

Autor: Karina, Knorr, So Won, Oh, Markus, Krönke, Alexander, Wurzer, Calogero, D'Alessandria, Michael, Herz, Wolfgang, Weber, Hans-Jürgen, Wester, Matthias, Eiber, Nahid, Yusufi, Stephan, Nekolla
Rok vydání: 2021
Zdroj: EJNMMI research. 12(1)
ISSN: 2191-219X
Popis: Radiohybrid prostate-specific membrane antigen (rhPSMA) ligands such asPreclinical dosimetry was performed with SCID-mice sacrificed at multiple timepoints (10-300 min) post-injection of 25.6 ± 3.6 MBqPreclinical dosimetry revealed that at 3.5 h and 1 h bladder voiding intervals, the extrapolated total effective doses were 26.6 and 12.2 µSv/MBq forRadiation dosimetry is favourable for both agents. Radiation exposure, assuming a 1 h voiding interval, is less than 5 mSv after injection of 370 MBq.
Databáze: OpenAIRE