Mesenchymal stem cell therapy to promote limb transplant functional recovery

Autor:	Emilie B, Fitzpatrick, Mary J, Dehart, Tommy A, Brown, Shashikumar K, Salgar
Rok vydání:	2015
Předmět:	Male Analysis of Variance Disease Models Animal Random Allocation Wound Healing Rats Inbred Lew Graft Survival Animals Recovery of Function Plastic Surgery Procedures Mesenchymal Stem Cell Transplantation Hindlimb Rats
Zdroj:	Microsurgery. 37(3)
ISSN:	1098-2752
Popis:	Limb transplantation is a viable option for reconstruction after traumatic limb loss; however, functional recovery can be suboptimal. The aim of this study was to determine whether mesenchymal stem cell (MSC) administration can improve limb transplant functional recovery.Orthotopic syngeneic hindlimb transplants were performed in Lewis rats, followed by topical and intravenous injections of syngeneic MSCs (5 × 10MSCs expanded ex vivo were CD29Bone marrow-derived MSC therapy appears to improve sensory function recovery in a rat limb transplant model. Published 2016. This article is a U.S. Government work and is in the public domain in the USA Microsurgery 37:222-234, 2017.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::55069b94d7159b05b06c27dfb8284fc3 https://pubmed.ncbi.nlm.nih.gov/27220027 Zobrazit plný text záznamu Plný text