| Autor: |
G V, Pogosova, O A, Gudkova, Iu M, Iufereva, E A, Tikhomirova |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Kardiologiia. 44(10) |
| ISSN: |
0022-9040 |
| Popis: |
Patients (n=28) with mild to moderate hypertension and depression were given enalapril (20 mg/day). If target blood pressure was not achieved in 10 days hydrochlorothiazide (12.5 mg/day) was added. These patients were randomized into 2 groups in one of which antihypertensive therapy was supplemented with citalopram (20 mg/day) for 6 weeks. Psychological status was assessed by Beck Depression Inventory (BDI) and Spielberger State-Trait Anxiety Inventory (STAI). Total BDI score in citalopram group decreased 51% (-12.2+/-1.5; p0.001). Complete reduction of symptoms of depression (BDI score19) occurred in 86% of patients. There was no significant lowering of BDI score in control group. STAI score among citalopram treated patients with concomitant anxiety (STAI score50) decreased from initial 62.9+/-2.1 to 46.3+/-3.1 by week 6 (p0.001). Only minor changes of STAI score took place in control group. According to data of 24-hour monitoring lowering of systolic blood pressure time indexes was somewhat more pronounced in citalopram group than in control group (24 hour -49.8 and -34.4%, diurnal -56.6 and -42%, nocturnal -37.9 and -23%, respectively). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
