| Autor: |
Francisco, Boix, José Miguel, Bolarín, Anna, Mrowiec, Jorge, Eguía, Gema, Gonzalez-Martinez, Jesús, de la Peña, José A, Galian, Rafael, Alfaro, María R, Moya-Quiles, Isabel, Legaz, José A, Campillo, Pablo, Ramírez, Ana, García-Alonso, Jose A, Pons, Francisco, Sánchez-Bueno, Alfredo, Minguela, Santiago, Llorente, Manuel, Muro |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Transplant immunology. 42 |
| ISSN: |
1878-5492 |
| Popis: |
The introduction of anti-calcineurin-based therapies has led to an increase in the one-year survival as well as graft function rates in patients undergoing solid organ transplantation (SOT). Nonetheless, early cellular acute rejection (EAR) incidence still remains a major challenge that irrevocably heads to poor outcomes. The mechanisms underlying CD4 T cell activation in SOT are still under research. In this sense, CD28 co-stimulatory molecule plays a pivotal role triggering CD4 T cell activation as well as survival maintenance. Previous own studies stated the role that CD4 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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