Escherichia coli brain abscess in a twin pair associated with TLR4 gene mutation

Autor:	Aydin, Erdemir, Zelal, Kahramaner, Hese, Cosar, Ebru, Turkoglu, Sumer, Sutcuoglu, Dilara Kocacik, Uygun, Olcay, Yegin, Afig, Berdeli, Esra Arun, Ozer
Rok vydání:	2012
Předmět:	Male Toll-Like Receptor 4 Mutation Diseases in Twins Escherichia coli Infant Newborn Brain Abscess Humans DNA Escherichia coli Infections
Zdroj:	Pediatrics international : official journal of the Japan Pediatric Society. 55(4)
ISSN:	1442-200X
Popis:	Brain abscesses are uncommon complications of bacterial meningitis or sepsis in neonates and infants. The causative pathogens of brain abscess in newborns are various. Of those, Escherichia coli is rarely seen as a pathogen in brain abscess at this age. Herein we reported brain abscesses in twin infants caused by E. coli sepsis. Interestingly, genetic analysis identified heterozygous Toll-like receptor 4 (TLR4) gene mutation in the twins. Because TLR plays an important role in the natural response to bacterial products and initiates specific immune response against these pathogens, this may explain the development of brain abscess in the present case.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::54d129d9b34296beb1a5f80db79bf2a6 https://pubmed.ncbi.nlm.nih.gov/23910802 Zobrazit plný text záznamu Plný text