| Autor: |
S, Petersen, C, Heckert, J, Rudolf, K, Schlüns, O I, Tchernitsa, R, Schäfer, M, Dietel, I, Petersen |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
International journal of cancer. 86(4) |
| ISSN: |
0020-7136 |
| Popis: |
Lung cancer is a highly aggressive neoplasm with 85% mortality. To identify new tumor-associated genes, we compared the expression profile of a primary metastasizing adenocarcinoma with normal airway epithelial cells. Two cDNA libraries of up- and downregulated genes were generated, comprising 253 and 299 clones, respectively. The sequence analysis revealed 205 different known genes and 314 cDNA fragments of unknown functions. Northern-blot analysis of 167 clones confirmed differential expression in 58%, and indicated a similar expression pattern in additional lung-cancer cell lines for selected clones, strengthening the value of this model for the identification of new candidate genes in lung carcinogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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