| Autor: |
M Kh, Gaĭnutdinov, V V, Konov, R N, Ishmukhamedov, E P, Kim, A K, Safarov |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Biokhimiia (Moscow, Russia). 59(2) |
| ISSN: |
0320-9725 |
| Popis: |
The pore with an effective diameter of 6.0 A is a Ca(2+)-channel of the inner mitochondrial membrane. Transport of nonelectrolytes through the pore is inhibited by ruthenium red, a specific Ca2+ transport inhibitor, and by polyanions which bind to the positively charged regions in the pore localized on the outer side of the inner mitochondrial membrane. The selectivity of Ca2+ ion transport into intact mitochondria is due to the binding of Ca2+ ions by the glycoprotein at the mouth of the pore as well as to electrostatic interactions of monovalent cations (electrostatic repulsion) and Cl- ions (strong binding) with the positively charged region of the ion-selective filter of the pore. Under normal conditions SCN- and NO3- ions are transferred through the pore at a high rate. Removal of Mg2+ ions and the rise in pH diminish the electrostatic repulsion of the monovalent cations and Cl- ions from the positively charged region of the pore. Depending on conditions, the pore can function as a monovalent ion transport system or as a mechanism of Cl- ion transfer through the inner mitochondrial membrane. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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