HDL

Autor:	Rahul, Chaudhary, Marija, Kinderytė, Rohit, Chaudhary, Ajaypaul, Sukhi, Kevin, Bliden, Udaya, Tantry, Paul, Gurbel
Rok vydání:	2018
Předmět:	Inflammation Male Cholesterol HDL Lipoproteins HDL3 Coronary Artery Disease Middle Aged Severity of Illness Index Lipoproteins LDL Cross-Sectional Studies Treatment Outcome Risk Factors Humans Female Hydroxymethylglutaryl-CoA Reductase Inhibitors Biomarkers Aged Dyslipidemias Lipoprotein(a)
Zdroj:	Cardiovascular revascularization medicine : including molecular interventions. 20(11)
ISSN:	1878-0938
Popis:	Low high-density lipoprotein (HDL-C) and inflammation are risk factors for coronary artery disease (CAD). However, limited data are available determining the role of HDL-C sub-particles HDLBlood samples were obtained prior to cardiac catheterization in 304 consecutive patients with suspected CAD on statin therapy in this sub-analysis of Multi-Analyte, thrombogenic, and Genetic Markers of Atherosclerosis (MAGMA, NCT01276678) study. Detailed lipid profiling and oxidized LDL (ox-LDL) were analyzed. CAD severity was angiographically defined as severe CAD (75% luminal diameter stenosis [LDS]) and non-severe CAD (≤75% LDS). Multi-regression analysis was performed to test for statistical significance. Receiver operator curve (ROC) analysis was performed to determine cut-point for predicting severe CAD.Patients with severe CAD had a significantly lower total-HDL-C, lower HDLIn patients on statin therapy, HDL
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5491a4fb693fd129054f6967346e46c4 https://pubmed.ncbi.nlm.nih.gov/31865981 Zobrazit plný text záznamu Full Text from ScienceDirect