| Autor: |
C I, Razafindrazoto, A S, Rasolonjatovo, N H, Randriamifidy, S S, Rabarioely, A L R, Rakotozafindrabe, T H, Rabenjanahary, S H, Razafimahefa, R M, Ramanampamonjy |
| Jazyk: |
francouzština |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Medecine tropicale et sante internationale. 1(3) |
| ISSN: |
2778-2034 |
| Popis: |
Our work aimed to assess the efficacy and safety of direct-acting antiviral drugs in the treatment of hepatitis C in Madagascar.This retrospective clinical study was carried out from March 2018 to February 2020 in the hepato-gastro-enterology department of the University Hospital Center Joseph Raseta de Befelatanana.A total of 35 patients were included, out of which 24 received sofosbuvir/ledipasvir ± ribavirin, 10 sofosbuvir/ribavirin and one sofosbuvir/velpatasvir. Thirty-three patients were naïve to the treatment and 2 patients were initially treated with the sofosbuvir/ledipasvir combination. The sustained virologic response was 94% (33/35) in the general population, 23/25 in cirrhotic patients and 10/10 in non-cirrhotic patients. The sustained virologic response was 22/24 for sofosbuvir/ledipasvir ± ribavirin, 10/10 for sofosbuvir/ribavirin and 1/1 for sofosbuvir/velpatasvir. Adverse effects were observed in 13 patients, mainly asthenia and insomnia.The small number of patients with hepatitis C treatments and their limited financial resources are the main limits of this survey.Direct-acting antivirals are effective and characterized by good tolerance in these Malagasy hepatitis C patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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