| Autor: |
Toshio, Ohhashi, Yoshiko, Kawai, Daisuke, Maejima, Moyuru, Hayashi, Tomomi, Watanabe-Asaka |
| Rok vydání: |
2022 |
| Zdroj: |
Lymphatic research and biology. |
| ISSN: |
1557-8585 |
| Popis: |
It is known that nitric oxide (NO) is a gas and synthesized from l-arginine by the NO synthase (NOS) in vascular endothelial cells. The diffused NO activates the guanosine monophosphate, which initiates a series of intracellular events, leading to physiological response such as vasodilation. There are three different types of NOS, namely endothelial constitutive NOS (ecNOS), neuronal NOS (nNOS), and cytokine-inducible NOS (iNOS). The ecNOS and nNOS are expressed constitutively at low levels and can be activated rapidly by an increase in cytoplasmic calcium ions. In contrast, the iNOS is induced when macrophages are activated by cytokine, resulting in the induction of pathophysiological effects. Lymph flow is known to stimulate the release of NO from lymphatic endothelial cells (LEC) and then produce the relaxation of lymphatic smooth muscle cells. The NO also plays a key role in the control of lymphatic pump activity |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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